HPV16 DNA status is a strong prognosticator of loco-regional control after postoperative radiochemotherapy of locally advanced oropharyngeal carcinoma: results from a multicentre explorative study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG).

@article{Lohaus2014HPV16DS,
  title={HPV16 DNA status is a strong prognosticator of loco-regional control after postoperative radiochemotherapy of locally advanced oropharyngeal carcinoma: results from a multicentre explorative study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG).},
  author={Fabian Lohaus and Annett Linge and Ingeborg Tinhofer and Volker Budach and Eleni Gkika and Annette Hoederath and Panagiotis Balermpas and Claus Michael R{\"o}del and Melanie Avlar and Anca Ligia Grosu and Amir Abdollahi and J{\"u}rgen Debus and Christine Bayer and Claus Belka and Steffi U. Pigorsch and Stephanie E Combs and David M{\"o}nnich and Daniel Zips and Cl{\"a}re von Neubeck and Gustavo Bruno Baretton and Steffen L{\"o}ck and Howard D. Thames and Mechthild Krause and Michael Baumann},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  year={2014},
  volume={113 3},
  pages={
          317-23
        }
}
OBJECTIVE To investigate the impact of HPV status in patients with locally advanced head and neck squamous cell carcinoma (HNSCC), who received surgery and cisplatin-based postoperative radiochemotherapy. MATERIALS AND METHODS For 221 patients with locally advanced squamous cell carcinoma of the hypopharynx, oropharynx or oral cavity treated at the 8 partner sites of the German Cancer Consortium, the impact of HPV DNA, p16 overexpression and p53 expression on outcome were retrospectively… CONTINUE READING
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