HPV and cervical cancer: updates on an established relationship.

  title={HPV and cervical cancer: updates on an established relationship.},
  author={Deepthi Subramanya and Petros Grivas},
  journal={Postgraduate medicine},
  volume={120 4},
Despite cervical cancer being considered a preventable disease, it still remains the second most common malignancy in women worldwide, with a higher incidence in underdeveloped countries. Human papillomavirus (HPV) is considered the causative agent of cervical cancer. The major mechanisms through which HPV contributes to neoplastic initiation and progression include the activity of 2 viral oncoproteins, E6 and E7, which interfere with critical cell cycle tumor suppressive proteins, p53 and… CONTINUE READING
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