HPV and Cervical Cancer: Updates on an Established Relationship

  title={HPV and Cervical Cancer: Updates on an Established Relationship},
  author={Deepthi Subramanya and Petros D. Grivas},
  journal={Postgraduate Medicine},
  pages={13 - 7}
Abstract Despite cervical cancer being considered a preventable disease, it still remains the second most common malignancy in women worldwide, with a higher incidence in underdeveloped countries. Human papillomavirus (HPV) is considered the causative agent of cervical cancer. The major mechanisms through which HPV contributes to neoplastic initiation and progression include the activity of 2 viral oncoproteins, E6 and E7, which interfere with critical cell cycle tumor suppressive proteins, p53… 
Human Papillomavirus DNA Testing: What, How, and When
The development of a preventive vaccine, the current versions of which appear to prevent close to 100% of persistent genital infection and disease caused by HPV-16 and HPV-18, may have a major impact on approaches to reduce the incidence of this disease.
Cervical cancer in sub-Saharan Africa: a preventable noncommunicable disease
The main issues discussed here are related to the public health burden of cervical cancer in sub-Saharan Africa and predictions for the coming decades, including molecular epidemiology and determinants of HPV infection in Africa, and promising prevention measures currently being evaluated in Africa.
The Prognostic Role of Human Papillomavirus in Patients With Vaginal Cancer
Human papillomavirus infection was frequently detected in squamous cell carcinoma of the vagina, and its presence may serve as a prognostic indicator in advanced stages.
The Association of the Immune Response Genes to Human Papillomavirus-Related Cervical Disease in a Brazilian Population
The KIR genes were not associated with HPV, although some pairs of i(inhibitory)KIR-ligands occurred more frequently in patients, supporting a role for NK in detrimental chronic inflammatory and carcinogenesis.
Novel Biomarkers in the Management of HPV-Positive & -Negative Oropharyngeal Carcinoma
Comparison of HPV-positive and -negative oropharyngeal carcinoma offers unprecedented insight into the biological significance of each aetiological agent, and how prognostication of each disease may relate to tumour behaviour at a molecular level.
Prevalence and distribution of Human Papillomavirus (HPV) genotypes among HIV infected women in Lomé, Togo
This study showed the diversity of circulating HPV genotypes in Togo and programs of HPV vaccination and early detection of benign or precancerous lesions should be implemented to reduce cancer-related comorbidities.
At the center of cervical carcinogenesis: synergism between high-risk HPV and the hyperactivated YAP1
It is found that synergism between hyperactivated YAP1 and high-risk HPV is a key driver of cervical cancer initiation and progression.
HPV and Cancer
Most infections with high-risk HPVs do not cause cancer, but infections that last for many years increase a person’s risk of developing cancer.
Role of E6/E7 mRNA in discriminating patients with high-risk human papilloma virus-positive associated with cytology-negative and atypical squamous cells of undetermined significance
E6/E7 mRNA can better discriminate the HPV16/18-positive patients with NILM from other HR-HPV- positive patients with ASCUS, and the positive predictive value (PPV) of CINII+ was increased and the difference was statistically significant.


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While waiting for clinically applicable vaccination programs, strategies to prevent cervical cancer include improved screening covering the widest possible population and using HPV testing, 2) close management and follow-up of women with precancerous lesions.
Co-fatores do HPV na oncogênese cervical
Possible co-factors of HPV in the genesis of the squamous carcinoma of uterine cervix are discussed, taking into account only the factors whose association with the virus or cervical cancer has been documented by experimental studies, and not based just on clinical or epidemiological data.
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Human papillomavirus: epidemiology and public health.
Clinicians and patients will need to shift discussions of the mildly abnormal Papanicolaou test to consideration of HPV infection as a common sexually transmitted infection that rarely causes cervical cancer.
Epidemiologic evidence showing that human papillomavirus infection causes most cervical intraepithelial neoplasia.
The data show that the great majority of all grades of CIN can be attributed to HPV infection, particularly with the cancer-associated types of HPV.
Epidemiologic classification of human papillomavirus types associated with cervical cancer.
In addition to HPV types 16 and 18, types 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73, and 82Should be considered carcinogenic, or high-risk, types, and types 26, 53, and 66 should be considered probably carcinogenic.
Type‐specific associations of human papillomavirus load with risk of developing cervical carcinoma in situ
The amount of HPV DNA for some of the most frequent high‐risk HPV types as determinants of progression to cervical CIS is studied to be predictive of future risk of cervical CIS at a stage when smears are negative for squamous abnormalities, but differences between HPV types need closer attention.