HPV Involvement in Head and Neck Cancers: Comprehensive Assessment of Biomarkers in 3680 Patients.

  title={HPV Involvement in Head and Neck Cancers: Comprehensive Assessment of Biomarkers in 3680 Patients.},
  author={Xavier Castellsagu{\'e} and Laia Alemany and Miquel Quer and Gordana Halec and Beatriz Quir{\'o}s and Sara Tous and Omar Clavero and Lluc{\`i}a Alos and Thorsten Biegner and Tomasz Szafarowski and Mar{\'i}a Alejo and Dana Holzinger and Enrique Cadena and Edith Claros and Gillian Hall and Jan Laco and Mario Poljak and Maria Benevolo and Elena Sachiko Kasamatsu and Hisham Mehanna and Cathy Ndiaye and N{\'u}ria Guimer{\`a} and Bel{\'e}n Lloveras and Xavier Le{\'o}n and Juan C Ruiz-Cabezas and Isabel Alvarado-Cabrero and Chang-Suk Kang and Jin Kyoung Oh and Marcial Garc{\'i}a-Rojo and Ermina Iljazovi{\'c} and O. B Fajemilehin Ajayi and Flora Duarte and Ashrafun Nessa and Leopoldo Tinoco and Marco A. Dur{\'a}n-Padilla and Edyta Catalina Pirog and Halina Viarheichyk and Hesler Morales and Val{\'e}rie Costes and Ana F{\'e}lix and Maria Julieta V Germar and Marisa Mena and Arzu Ruacan and Asha Jain and Ravi Mehrotra and Marc T. Goodman and Luis Estuardo Lombardi and Annabelle Ferrera and Sani Abubakar Malami and Estela I Albanesi and Pablo Dabed and Carla Molina and Rub{\'e}n L{\'o}pez-Revilla and V{\'a}clav Mandys and Manuel E Gonz{\'a}lez and Julio Velasco and Ignacio G. Bravo and Wim H Quint and Michael Pawlita and Nubia Mu{\~n}oz and Silvia de Sanjos{\'e} and F. Xavier Bosch},
  journal={Journal of the National Cancer Institute},
  volume={108 6},
BACKGROUND We conducted a large international study to estimate fractions of head and neck cancers (HNCs) attributable to human papillomavirus (HPV-AFs) using six HPV-related biomarkers of viral detection, transcription, and cellular transformation. METHODS Formalin-fixed, paraffin-embedded cancer tissues of the oral cavity (OC), pharynx, and larynx were collected from pathology archives in 29 countries. All samples were subject to histopathological evaluation, DNA quality control, and HPV… CONTINUE READING