HPV Involvement in Head and Neck Cancers: Comprehensive Assessment of Biomarkers in 3680 Patients.

  title={HPV Involvement in Head and Neck Cancers: Comprehensive Assessment of Biomarkers in 3680 Patients.},
  author={X. Castellsagu{\'e} and L. Alemany and M. Quer and G. Halec and Beatriz Quir{\'o}s and S. Tous and O. Clavero and L. Alos and Thorsten Biegner and Tomasz Szafarowski and M. Alejo and D. Holzinger and E. Cadena and Edith Claros and Gillian Hall and Jan Laco and Mario Poljak and M. Benevolo and Elena Kasamatsu and Hisham M. Mehanna and C. Ndiaye and N. Guimer{\`a} and B. Lloveras and X. L{\'e}on and Juan C Ruiz-Cabezas and I. Alvarado-Cabrero and Chang-Suk Kang and Jin-Kyoung Oh and Marcial Garc{\'i}a-Rojo and Ermina Iljazovic and O. F. Ajayi and Flora Duarte and A. Nessa and Leopoldo Tinoco and M. A. Dur{\'a}n-Padilla and E. Pirog and Halina Viarheichyk and Hesler Morales and Val{\'e}rie Costes and A. F{\'e}lix and M. J. Germar and M. Mena and A. Ruacan and A. Jain and R. Mehrotra and M. Goodman and L. E. Lombardi and Annabelle Ferrera and S. Malami and Estela I Albanesi and Pablo Dabed and C. Molina and Rub{\'e}n L{\'o}pez-Revilla and V{\'a}clav Mandys and M. E. Gonz{\'a}lez and Julio Velasco and I. Bravo and W. Quint and M. Pawlita and N. Mu{\~n}oz and S. de Sanjos{\'e} and F. Xavier Bosch},
  journal={Journal of the National Cancer Institute},
  volume={108 6},
  • X. Castellsagué, L. Alemany, +59 authors F. Xavier Bosch
  • Published 2016
  • Biology, Medicine
  • Journal of the National Cancer Institute
  • BACKGROUND We conducted a large international study to estimate fractions of head and neck cancers (HNCs) attributable to human papillomavirus (HPV-AFs) using six HPV-related biomarkers of viral detection, transcription, and cellular transformation. METHODS Formalin-fixed, paraffin-embedded cancer tissues of the oral cavity (OC), pharynx, and larynx were collected from pathology archives in 29 countries. All samples were subject to histopathological evaluation, DNA quality control, and HPV… CONTINUE READING

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    Publications referenced by this paper.
    HPV DNA, E6/E7 mRNA, and p16INK4a detection in head and neck cancers: a systematic review and meta-analysis.
    Biological activity of probable/possible high‐risk human papillomavirus types in cervical cancer