HPV E 6 , E 6 AP and cervical cancer

  title={HPV E 6 , E 6 AP and cervical cancer},
  author={Sylvie Beaudenon and Jon M Huibregtse},
Every year, approximately 470,000 new cases of cervical cancer are diagnosed and approximately 230,000 women worldwide die of the disease, with the majority (~80%) of these cases and deaths occurring in developing countries. Human papillomaviruses (HPVs) are the etiological agents in nearly all cases (99.7%) of cervical cancer, and the HPV E6 protein is one of two viral oncoproteins that is expressed in virtually all HPV-positive cancers. E6 hijacks a cellular ubiquitin ligase, E6AP, resulting… CONTINUE READING


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Pavletich NP: Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme

  • L Huang, E Kinnucan, G Wang, S Beaudenon, PM Howley, JM Huibregtse
  • 1999
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