HPV-16 infection modifies overall survival of Puerto Rican HNSCC patients


HPV-16 modifies the overall survival (OS) of patients with oropharyngeal cancer (OPSCC). HPV-16 has been established as risk factor for OPSCC, but HPV-16 infection may also reside in the larynx and oral cavity. We evaluated HPV-16 status on OS of Head and Neck Squamous Cell Carcinoma (HNSCC) patients. HPV-16 infection was confirmed by amplification of E6 and E7 viral oncogenes through PCR assay and E6 IHC in 185 HNSCC samples. Associations between HPV-16 status and clinicopathological parameters were performed using Fisher’s exact test and x2. Survival analysis was completed using Kaplan-Meier estimator and multivariate Cox regression analysis. OS of HPV-16 positive patients was longer compared to HPV-16 negative patients (P = 0.002). HPV-16 positive tumors of the larynx (LSCC) and pharynx (PSCC) showed improved OS compared to HPV-16 negative tumors. Also, HPV-16 positive patients exposed to radiotherapy presented a better survival. HPV-16 status has a positive prognostic value in HNSCC. Addition of HPV-16 status to the TNM staging can provide better assessment in prognosis and guide treatment for HNSCC patients.

DOI: 10.1186/s13027-016-0095-4

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@inproceedings{RiveraPea2016HPV16IM, title={HPV-16 infection modifies overall survival of Puerto Rican HNSCC patients}, author={Bianca Rivera-Pe{\~n}a and Francisco J Ru{\'i}z-Fullana and Germ{\'a}n L V{\'e}lez-Reyes and Rosa J Rodr{\'i}guez-Benitez and Mar{\'i}a J. Marcos-Mart{\'i}nez and Juan Trinidad-Pinedo and Adriana B{\'a}ez}, booktitle={Infectious Agents and Cancer}, year={2016} }