HPMC as a potential enhancer of nimodipine biopharmaceutical properties via ball-milled solid dispersions.

@article{Riekes2014HPMCAA,
  title={HPMC as a potential enhancer of nimodipine biopharmaceutical properties via ball-milled solid dispersions.},
  author={Manoela Kl{\"u}ppel Riekes and Gislaine Kuminek and Gabriela Schneider Rauber and Carlos Eduardo Maduro de Campos and Ada{\'i}lton Jo{\~a}o Bortoluzzi and Hellen Karine Stulzer},
  journal={Carbohydrate polymers},
  year={2014},
  volume={99},
  pages={474-82}
}
The poor solubility of drugs remains one of the most challenging aspects of formulation development. Aiming at improving the biopharmaceutical limitations of the calcium channel blocker nimodipine, the development of solid dispersions is proposed herein. Three different proportions of nimodipine:HPMC were tested and all of them generated amorphous solid dispersions. Improvements of up 318% in the solubility and a 4-fold increase in the dissolution rate of nimodipine were achieved. Stability… CONTINUE READING

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