HPLC with electrochemical detection to measure chlorpromazine, thioridazine and metabolites in human brain

Abstract

Thirteen phenothiazine compounds were separated chromatographically using high performance liquid chromatography with coulometric electrochemical detection. These could be extracted from brain tissue using direct homogenization in tetrahydrofuran followed by one centrifugation, evaporation of supernatant and reconstitution in water. Fluphenazine was used as… (More)
DOI: 10.1007/BF00179183

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