HPLC separation of dihydropyridine derivatives enantiomers with emphasis on elution order using polysaccharide-based chiral columns.

@article{Jibuti2012HPLCSO,
  title={HPLC separation of dihydropyridine derivatives enantiomers with emphasis on elution order using polysaccharide-based chiral columns.},
  author={George Jibuti and Antonina Mskhiladze and Nino Takaishvili and Marina Karchkhadze and Lali Chankvetadze and Tivadar Farkas and Bezhan Chankvetadze},
  journal={Journal of separation science},
  year={2012},
  volume={35 19},
  pages={
          2529-37
        }
}
The separation of enantiomers of five chiral dihydropyridine derivatives was studied on five different polysaccharide-based chiral HPLC columns with various normal-phase (NP), polar organic, and reversed-phase eluents. Along with the successful separation of analyte enantiomers, the emphasis of this study was on enantiomer elution order (EEO) with various columns and mobile phase composition. The interesting phenomenon of reversal of EEO, recently reported in the case of amlodipine (AML… CONTINUE READING
BETA
1
Twitter Mention

Citations

Publications citing this paper.
SHOWING 1-7 OF 7 CITATIONS

Similar Papers

Loading similar papers…