HPLC method for determination of diclofenac in human plasma and its application to a pharmacokinetic study in Turkey.

@article{Yilmaz2011HPLCMF,
  title={HPLC method for determination of diclofenac in human plasma and its application to a pharmacokinetic study in Turkey.},
  author={Bilal Yilmaz and Ali Erkan Asci and Saziye Sezin Palabiyik},
  journal={Journal of chromatographic science},
  year={2011},
  volume={49 6},
  pages={422-7}
}
A simple high-performance liquid chromatography (HPLC) method has been developed for determination of diclofenac in human plasma. The method was validated on Ace C(18) column using UV detection. The mobile phase consisted of 20 mM phosphate buffer (pH 7) containing 0.1% trifluoroacetic acid-acetonitrile (65:35, v/v). Calibration curve was linear between the concentration range of 75-4000 ng/mL. Intra- and inter-day precision values for diclofenac in plasma were less than 3.6, and accuracy… CONTINUE READING
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