HPLC-fluorescence assay for measuring mosapride in small volumes of rat plasma.

A simple and sensitive HPLC-fluorescence assay was developed for the determination of a gastroprokinetic agent mosapride in small volumes of rat plasma. Samples (50 microL) were treated with 200 microL of the internal standard solution (cisapride, 0.1 microg/mL in acetonitrile). Chromatographic separation was achieved on a C(18) column by gradient elution… CONTINUE READING