HPLC-MS method for the simultaneous quantification of the antileukemia drugs imatinib, dasatinib and nilotinib in human peripheral blood mononuclear cell (PBMC).

Abstract

A new method using high performance liquid chromatography coupled with electrospray mass spectrometry is described for the quantification of PBMC concentration of tyrosine kinase inhibitors imatinib, dasatinib and nilotinib. A simple PBMC isolation and extraction procedure were applied on 10-14 mL of blood aliquots. Chromatographic separation of drugs and… (More)
DOI: 10.1016/j.jpba.2011.10.003

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Cite this paper

@article{DAvolio2012HPLCMSMF, title={HPLC-MS method for the simultaneous quantification of the antileukemia drugs imatinib, dasatinib and nilotinib in human peripheral blood mononuclear cell (PBMC).}, author={Antonio D'Avolio and M. Simiele and Silvia De Francia and Alessandra Ariaudo and Lorena Baietto and Jessica Cusato and Carmen Fava and Giuseppe Saglio and Francesco Di Carlo and Giovanni di Perri}, journal={Journal of pharmaceutical and biomedical analysis}, year={2012}, volume={59}, pages={109-16} }