HPLC-MS/MS method for quantification of paclitaxel from keratin containing samples.

@article{Turner2017HPLCMSMSMF,
  title={HPLC-MS/MS method for quantification of paclitaxel from keratin containing samples.},
  author={Emily A Turner and Alexandra C. Stenson and Saami K Yazdani},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2017},
  volume={139},
  pages={
          247-251
        }
}
Local drug delivery of paclitaxel is becoming ever more prevalent. As complex drug/excipient combinations are being developed and tested, new high performance liquid chromatography-mass spectrometry (HPLC-MS) techniques capable of quantifying paclitaxel from such formulations are needed. Here a method for quantifying paclitaxel from aqueous, protein and oil containing samples was developed and validated. Keratin, derived from human hair, is the protein component/paclitaxel excipient in the… CONTINUE READING
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