HPIP promotes epithelial-mesenchymal transition and cisplatin resistance in ovarian cancer cells through PI3K/AKT pathway activation

@article{Bugide2016HPIPPE,
  title={HPIP promotes epithelial-mesenchymal transition and cisplatin resistance in ovarian cancer cells through PI3K/AKT pathway activation},
  author={Suresh Bugide and Vijay Kumar Gonugunta and Vasudevarao Penugurti and Vijaya Lakshmi Malisetty and Ratna K Vadlamudi and Bramanandam Manavathi},
  journal={Cellular Oncology},
  year={2016},
  volume={40},
  pages={133-144}
}
Hematopoietic PBX interacting protein (HPIP), a scaffold protein, is known to regulate the proliferation, migration and invasion in different cancer cell types. The aim of this study was to assess the role of HPIP in ovarian cancer cell migration, invasion and epithelial-mesenchymal transition (EMT), and to unravel the mechanism by which it regulates these processes. HPIP expression was assessed by immunohistochemistry of tissue microarrays containing primary ovarian tumor samples of different… CONTINUE READING
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