HPA-axis regulation at in-patient admission is associated with antidepressant therapy outcome in male but not in female depressed patients

@article{Binder2009HPAaxisRA,
  title={HPA-axis regulation at in-patient admission is associated with antidepressant therapy outcome in male but not in female depressed patients},
  author={Elisabeth B. Binder and Heike E. Kuenzel and Thomas Nickel and Naomi Kern and Florian Holsboer},
  journal={Psychoneuroendocrinology},
  year={2009},
  volume={34},
  pages={99-109}
}
A concatenation of data implicates a hyperactivity of the hypothalamus pituitary adrenal (HPA)-axis in the pathogenesis of depression and its normalization as a necessary predecessor of clinical response to antidepressant drugs. In addition, regulation of the HPA-axis has been shown to be dependent on sex hormones. We therefore investigated gender differences in HPA-axis regulation in depression and its normalization during remission of clinical symptoms. We used the combined dexamethasone… CONTINUE READING

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