HPA Axis Genetic Variation, Cortisol, and Psychosis in Major Depression

  title={HPA Axis Genetic Variation, Cortisol, and Psychosis in Major Depression},
  author={Alan F. Schatzberg and Jennifer N. Keller and Lakshika Tennakoon and Anna Lembke and Gordon H. Williams and Fredric B Kraemer and Jane E. Sarginson and Laura C Lazzeroni and Greer M. Murphy},
  booktitle={Molecular Psychiatry},
Genetic variation underlying hypothalamic pituitary adrenal (HPA) axis overactivity in healthy controls (HCs) and patients with severe forms of major depression has not been well explored, but could explain risk for cortisol dysregulation. In total, 95 participants were studied: 40 patients with psychotic major depression (PMD); 26 patients with non-psychotic major depression (NPMD); and 29 HCs. Collection of genetic material was added one third of the way into a larger study on cortisol… CONTINUE READING
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