HP1 binds specifically to Lys26-methylated histone H1.4, whereas simultaneous Ser27 phosphorylation blocks HP1 binding.

@article{Daujat2005HP1BS,
  title={HP1 binds specifically to Lys26-methylated histone H1.4, whereas simultaneous Ser27 phosphorylation blocks HP1 binding.},
  author={Sylvain Daujat and Ulrike Zeissler and Tanja Waldmann and Nicole Happel and Robert Schneider},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 45},
  pages={
          38090-5
        }
}
Histone lysine methylation can have positive or negative effects on transcription, depending on the precise methylation site. According to the "histone code" hypothesis these methylation marks can be read by proteins that bind them specifically and then regulate downstream events. Hetero-chromatin protein 1 (HP1), an essential component of heterochromatin, binds specifically to methylated Lys(9) of histone H3 (K9/H3). The linker histone H1.4 is methylated on Lys(26) (K26/H1.4), but the role of… CONTINUE READING
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