HP1-β is required for development of the cerebral neocortex and neuromuscular junctions

@article{Aucott2008HP1IR,
  title={HP1-$\beta$ is required for development of the cerebral neocortex and neuromuscular junctions},
  author={Rebecca L. Aucott and J. Bullwinkel and Yang Yu and W. Shi and Mustafa Billur and Jeremy P. Brown and U. Menzel and D. Kioussis and Guozheng Wang and I. Reisert and J. Weimer and R. Pandita and G. Sharma and T. Pandita and R. Fundele and Prim B. Singh},
  journal={The Journal of Cell Biology},
  year={2008},
  volume={183},
  pages={597 - 606}
}
HP1 proteins are thought to be modulators of chromatin organization in all mammals, yet their exact physiological function remains unknown. In a first attempt to elucidate the function of these proteins in vivo, we disrupted the murine Cbx1 gene, which encodes the HP1-β isotype, and show that the Cbx1−/−-null mutation leads to perinatal lethality. The newborn mice succumbed to acute respiratory failure, whose likely cause is the defective development of neuromuscular junctions within the… Expand
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Up‐regulation of HP1γ expression during neuronal maturation promotes axonal and dendritic development in mouse embryonic neocortex
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