HOXC9 links cell-cycle exit and neuronal differentiation and is a prognostic marker in neuroblastoma.

@article{Mao2011HOXC9LC,
  title={HOXC9 links cell-cycle exit and neuronal differentiation and is a prognostic marker in neuroblastoma.},
  author={Lijun Mao and Jane Ding and Yun-hong Zha and Liqun Yang and Brian A. McCarthy and William W. King and Hongjuan Cui and H T Ding},
  journal={Cancer research},
  year={2011},
  volume={71 12},
  pages={4314-24}
}
Differentiation status in neuroblastoma strongly affects clinical outcomes and inducing differentiation is a treatment strategy in this disease. However, the molecular mechanisms that control neuroblastoma differentiation are not well understood. Here, we show that high-level HOXC9 expression is associated with neuroblastoma differentiation and is prognostic for better survival in neuroblastoma patients. HOXC9 induces growth arrest and neuronal differentiation in neuroblastoma cells by directly… CONTINUE READING

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