HOXB9, a gene overexpressed in breast cancer, promotes tumorigenicity and lung metastasis.

@article{Hayashida2010HOXB9AG,
  title={HOXB9, a gene overexpressed in breast cancer, promotes tumorigenicity and lung metastasis.},
  author={Tetsu Hayashida and Fumiyuki Takahashi and Naokazu Chiba and Elena F. Brachtel and Motomi Takahashi and Nadia Godin-Heymann and Kenneth W. Gross and Maria dM. Vivanco and Vasuki Wijendran and Toshihiro Shioda and Dennis C. Sgroi and Patricia K Donahoe and S. Maheswaran},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 3},
  pages={1100-5}
}
The mechanisms underlying tumoral secretion of signaling molecules into the microenvironment, which modulates tumor cell fate, angiogenesis, invasion, and metastasis, are not well understood. Aberrant expression of transcription factors, which has been implicated in the tumorigenesis of several types of cancers, may provide a mechanism that induces the expression of growth and angiogenic factors in tumors, leading to their local increase in the tumor microenvironment, favoring tumor progression… CONTINUE READING