HOXB4-Induced Expansion of Adult Hematopoietic Stem Cells Ex Vivo

  title={HOXB4-Induced Expansion of Adult Hematopoietic Stem Cells Ex Vivo},
  author={Jennifer L Antonchuk and Guy Sauvageau and R. Keith Humphries},
Hox transcription factors have emerged as important regulators of primitive hematopoietic cell proliferation and differentiation. In particular, HOXB4 appears to be a strong positive regulator of hematopoietic stem cell (HSC) self-renewal. Here we demonstrate the potency of HOXB4 to enable high-level ex vivo HSC expansion. Cultures of nontransduced or GFP-transduced murine bone marrow cells experienced large HSC losses over 10-14 days. In sharp contrast, cultures of HOXB4-transduced cells… CONTINUE READING
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HOXB4 overexpression mediates very rapid stem cell regeneration and ing: A Laboratory Manual

  • J. Antonchuk, G. Sauvageau, R. K. Humphries
  • (Cold Spring Harbor,
  • 2001
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