HOX genes and their role in the development of human cancers

@article{Bhatlekar2014HOXGA,
  title={HOX genes and their role in the development of human cancers},
  author={Seema Bhatlekar and Jeremy Z. Fields and Bruce M Boman},
  journal={Journal of Molecular Medicine},
  year={2014},
  volume={92},
  pages={811-823}
}
In this review, we summarize published findings on the involvement of HOX genes in oncogenesis. HOX genes are developmental genes—they code for proteins that function as critical master regulatory transcription factors during embryogenesis. Many reports have shown that the protein products of HOX genes also play key roles in the development of cancers. Based on our review of the literature, we found that the expression of HOX genes is not only up- or downregulated in most solid tumors but also… Expand
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TLDR
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TLDR
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TLDR
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Analysis of expression patterns of putative candidate HOX genes involved in breast cancer tumorigenesis and progression using breast cancer cell lines and patient-derived breast tissues revealed that HOXA and HOXB gene expression occurred in a subtype-specific manner in breastcancer cell lines, whereas most HOXC genes were strongly expressed in most cell lines. Expand
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