HOX and Non‐HOX Homeobox Genes in Leukemic Hematopoiesis

@article{Owens2002HOXAN,
  title={HOX and Non‐HOX Homeobox Genes in Leukemic Hematopoiesis},
  author={Bronwyn M. Owens and Robert G. Hawley},
  journal={STEM CELLS},
  year={2002},
  volume={20}
}
Dysregulation of homeobox (HB)‐containing genes is becoming increasingly recognized as the underlying basis of many hematologic malignancies. Expression of clustered HB (HOX) genes within the hematopoietic system, and enforced overexpression and knockout studies have provided support for the concept that these homeodomain‐containing transcription factors play a significant role in the developmental biology of hematopoietic cells. Diverged HB (non‐HOX) genes have recently been identified as… 
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Hox genes in hematopoiesis and leukemogenesis
TLDR
It is proposed that Hox-dependent pathways are closely linked to the self-renewal program crucial to the origin and function of leukemic stem cells.
Hox regulation of normal and leukemic hematopoietic stem cells
TLDR
The identification of Hox genes as HSC regulators has been exploited to develop strategies to efficiently expand HSCs ex vivo, a key step to the success of therapies based on HSC transplantation and the understanding of mechanisms underlying HSC regulation.
Hox gene dysregulation in acute myeloid leukemia.
TLDR
Hex genes dysregulation is a dominant mechanism of leukemic transformation and a better knowledge of their target genes and the mechanisms by which their dysregulated expression contributes to leukemogenesis could lead to the development of new drugs.
Beyond Hox: the role of ParaHox genes in normal and malignant hematopoiesis.
TLDR
Correlative studies indicate that CDX2 functions as master regulator of perturbed HOX gene expression in human acute myeloid leukemia, locating this ParaHox gene at a central position for initiating and maintaining HOX genes dysregulation as a driving leukemogenic force.
HOX proteins and leukemia.
HOX and three amino acid loop extension (TALE) proteins cooperate to induce transformation in mouse leukemia models, and are dysregulated in a variety of human leukemias. Despite decades of research,…
Epigenetic regulations in hematopoietic Hox code
TLDR
A combinatorial axial model of hematopoietic Hox code is proposed to predict the positional identity of the hematopolietic cells and will provide new insight into epigenetic therapy in leukemia.
erythroid/megakaryocyte development HOXA10 is a critical regulator for hematopoietic stem cells and
TLDR
The HOXA10-mediated effects on hematopoietic cells were associated with altered expression of genes that govern stem cell self-renewal and lineage commitment, demonstrating that tight regulation of HOxA10 is critical for normal development of the erythroid and megakaryocytic lineages.
Specific homeodomain-DNA interactions are required for HOX11-mediated transformation.
TLDR
It is concluded that dysregulated expression of a particular set of downstream target genes by DNA binding via the homeodomain is of central importance for leukemia initiation mediated by HOX11.
Characterization of the Proteins HPIP and VENTX2 as Novel Regulatory Proteins of Human Hematopoiesis
TLDR
Hospital-like Homeobox gene HPIP is characterized as a novel regulator of the early human hematopoietic stem cell, demonstrating that its constitutive expression has a notable impact on self renewal and differentiation of human heMatopoieic stem cells.
Hematopoietic immortalizing function of the NKL‐subclass homeobox gene TLX1
TLDR
By linker‐mediated nested polymerase chain reaction the integration sites in eight TLX1‐immortalized hematopoietic cell lines were determined and unequivocally rule out insertions into Evi1 and Prdm16 as being integral to the TLX 1‐initiated immortalization process.
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