HOX Gene Links Limb, Genital Defects

@article{Dickman1997HOXGL,
  title={HOX Gene Links Limb, Genital Defects},
  author={Steven Dickman},
  journal={Science},
  year={1997},
  volume={275},
  pages={1568 - 1568}
}
The HOX gene family has helped to unlock the intricacies of development in animals from flies to mammals, but its role in humans has been a mystery. Now the second human HOX gene mutation has been found in a Michigan family. It causes abnormalities in both limbs and genitals—and raises some intriguing evolutionary ideas. 
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