HOX Gene Links Limb, Genital Defects

  title={HOX Gene Links Limb, Genital Defects},
  author={Steven Dickman},
  pages={1568 - 1568}
The HOX gene family has helped to unlock the intricacies of development in animals from flies to mammals, but its role in humans has been a mystery. Now the second human HOX gene mutation has been found in a Michigan family. It causes abnormalities in both limbs and genitals—and raises some intriguing evolutionary ideas. 
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Teleosts, the most species-rich group of vertebrates, appear to have more copies of these developmental regulatory genes than do mammals, despite less complexity in the anterior-posterior axis.
Hox cluster organization in the jawless vertebrate Petromyzon marinus.
Gene phylogenies suggest that the lamprey has at least four Hox clusters and support the model that gnathostome H Cox clusters arose by a two-round-no-cluster-loss mechanism, with tree topology [(AB)(CD)].
Quirks of Human Anatomy: An Evo-Devo Look at the Human Body
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Prenatal Influences on Human Sexual Orientation: Expectations versus Data
The data indicate that human sexual orientation is sufficiently polarized that groups of lesbians show evidence of greater prenatal androgen exposure than groups of straight women, while groups of gay men have, on average, a greater proportion of brothers among their older siblings than do straight men.
Do psychotherapies produce neurobiological effects?
  • V. Kumari
  • Psychology, Medicine
    Acta Neuropsychiatrica
  • 2006
Investigation of changes in neural activity with psychological therapies is a novel area which is likely to enhance the understanding of the mechanisms for therapeutic changes across a range of disorders.
IsSchindewolf’s “Grundfragen der Paläontologie” still worth reading? An apologetic evaluation of his work
KurzfassungVor gut fünf Jahren erschien O.H. Schindewolf’s Werk “Grundfragen der Paläontologie” - fast ein halbes Jahrhundert nach der deutschen Ausgabe — zum ersten Mal in englischer Sprache. Damit
Anti-Mullerian Hormone: Molecular Mechanism of Action
The roles of two testicular hormones, testosterone and anti-Mullerian hormone (AMH), which are essential for proper differentiation of the internal genitalia, are discussed.