HOW is required for stem cell maintenance in the Drosophila testis and for the onset of transit-amplifying divisions.

@article{Monk2010HOWIR,
  title={HOW is required for stem cell maintenance in the Drosophila testis and for the onset of transit-amplifying divisions.},
  author={Adrian C. Monk and Nicole A. Siddall and Talila Volk and Barbara Fraser and Leonie M Quinn and Eileen A McLaughlin and Gary R Hime},
  journal={Cell stem cell},
  year={2010},
  volume={6 4},
  pages={348-60}
}
The mechanisms by which germline stem cells (GSCs) in the Drosophila testis undergo asymmetric division to regenerate a stem cell as well as a daughter (gonialblast) that will only undergo a further four mitotic divisions prior to entering premeiotic S phase and differentiating into a cyst of spermatocytes are not fully resolved. Here we demonstrate that the HOW RNA-binding protein is required for maintenance of CycB and therefore mitotic progression in GSCs and gonialblasts as well as… CONTINUE READING