HOT regions function as patterned developmental enhancers and have a distinct cis-regulatory signature.

@article{Kvon2012HOTRF,
  title={HOT regions function as patterned developmental enhancers and have a distinct cis-regulatory signature.},
  author={Evgeny Z. Kvon and Gerald Stampfel and J. Omar Y{\'a}{\~n}ez-Cuna and Barry J. Dickson and Alexander Stark},
  journal={Genes & development},
  year={2012},
  volume={26 9},
  pages={908-13}
}
HOT (highly occupied target) regions bound by many transcription factors are considered to be one of the most intriguing findings of the recent modENCODE reports, yet their functions have remained unclear. We tested 108 Drosophila melanogaster HOT regions in transgenic embryos with site-specifically integrated transcriptional reporters. In contrast to prior expectations, we found 102 (94%) to be active enhancers during embryogenesis and to display diverse spatial and temporal patterns… CONTINUE READING
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