HOSCN is a more potent inducer of apoptosis and protein thiol depletion in murine macrophage cells than HOCl or HOBr

@inproceedings{Lloyd2012HOSCNIA,
  title={HOSCN is a more potent inducer of apoptosis and protein thiol depletion in murine macrophage cells than HOCl or HOBr},
  author={Mitchell M. Lloyd and David M. van Reyk and Michael J Davies and C L Hawkins},
  year={2012}
}
Hypohalous acids are generated by activated leukocytes, via the formation of H2O2 and the release of peroxidase enzymes (myeloperoxidase, eosinophil peroxidase). These species are important bactericidal agents, but hypochlorous acid (HOCl) and hypobromous acid (HOBr) have also been implicated in tissue damage in a number of inflammatory diseases. Hypothiocyanous acid (HOSCN) is a milder, more thiol-specific, oxidant than HOCl or HOBr, and as such may be a more potent inducer of cellular… CONTINUE READING
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