HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin.

@article{Fuchs1999HOSAH,
  title={HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin.},
  author={Serge Yu. Fuchs and Angus Chen and Yue Xiong and Z. Q. Pan and Ze'ev A Ronai},
  journal={Oncogene},
  year={1999},
  volume={18 12},
  pages={2039-46}
}
SCF E3 ubiquitin ligases mediate ubiquitination and proteasome-dependent degradation of phosphorylated substrates. We identified a human F-box/WD40 repeats protein (HOS), which is homologous to Slimb/h betaTrCP. Being a part of SCF complex with Skp1 and Cullin1, HOS specifically interacted with the phosphorylated IkappaB and beta-catenin, targeting these… CONTINUE READING