HORMONAL PROTECTION OF RATS BREATHING OXYGEN AT HIGH PRESSURE1,2

@article{Troy1972HORMONALPO,
  title={HORMONAL PROTECTION OF RATS BREATHING OXYGEN AT HIGH PRESSURE1,2},
  author={Shuang S. Troy and Donald Herbert Ford},
  journal={Acta Neurologica Scandinavica},
  year={1972},
  volume={48}
}
  • S. Troy, D. Ford
  • Published 1 May 1972
  • Biology, Medicine
  • Acta Neurologica Scandinavica
Sex differences in susceptibility to high pressure oxygen (OHP)‐induced convulsions were observed in mature rats. Male rats convulsed significantly earlier than did females. After adrenalectomy, seizures disappeared in most females and some male rats. The number of adrenalectomized male rats which resisted OHP‐induced convulsions increased from 40 % to 91 % when they were treated with estradiol subcutaneously. Rats which do not convulse during the exposure to OHP eventually develop pulmonary… 
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  • Medicine
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References

SHOWING 1-10 OF 38 REFERENCES
Development of a strain of rats with greater than normal susceptibility to oxygen poisoning.
  • J. Wood
  • Biology, Medicine
    Canadian journal of physiology and pharmacology
  • 1966
TLDR
Male and female rats of the Wistar strain exposed to oxygen at high pressure (OHP) once per week for 3 weeks were selected which were considered the most susceptible and the most resistant to oxygen poisoning.
The gonad-brain relationship: effects of female sex hormones on electroshock convulsions in the rat.
The effects of ovariectomy and ovarian hormones on brain excitability were investigated in rats by measuring: (a) minimal electroshock seizure threshold, and (b) maximal electroshock seizure pattern.
Variation in Response to Hyperbaric Oxygen among Inbred Strains of Mice∗
  • G. Hill, S. Osterhout, W. O'Fallon
  • Biology
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1968
TLDR
Oxygen resistant mouse strains useful in evaluating HBO as a therapeutic agent for certain disease states have been delineated and comparative studies of the inherent biochemical and physiological characteristics of these susceptible and resistant inbred strains could be useful in efforts to elucidate mechanisms of oxygen toxicity.
CORRELATION BETWEEN DECREASES IN BRAIN γ‐AMINOBUTYRIC ACID LEVELS AND SUSCEPTIBILITY TO CONVULSIONS INDUCED BY HYPERBARIC OXYGEN 1
TLDR
A correlation between the rate of decrease in GABA and susceptibility to seizures was shown to exist not only over the varying oxygen pressures and varying concentrations of carbon dioxide used in the present experiments out also over varying animal species.
A COMPARATIVE STUDY OF HYPERBARIC OXYGENINDUCED AND DRUG‐INDUCED CONVULSIONS WITH PARTICULAR REFERENCE TO γ‐AMINOBUTYRIC ACID METABOLISM *
TLDR
The present experimental approach has been to compare OHP-induced convulsions with seizures caused by various well known convulsant drugs in the belief that the results so obtained might shed further light on the biochemical mechanisms involved in O HP-induced seizures.
Effect of a progestogen and an oestrogen on the γ‐aminobutyric acid content in the cerebral hemispheres of ovariectomized rats
  • S. Saad
  • Biology, Psychology
    The Journal of pharmacy and pharmacology
  • 1970
TLDR
The increase in GABA content in the cerebral hemispheres 30 days after ovariectomy of adult female rats amounts to 20% above the normal value, which appears to be the reverse of the effect of castration on GABA content.
Effect of adrenocortical steroids and adrenocorticotrophic hormone on electroshock seizure threshold.
  • D. Woodbury
  • Biology, Medicine
    The Journal of pharmacology and experimental therapeutics
  • 1952
TLDR
The effect of six adrenocortical steroids on the electroshock seizure threshold (EST) of rats has been tested and DCA, given in combination with cortis one acetate, inhibited the decrease in EST observed after cortisone acetate alone.
THE REGIONAL EFFECTS OF ADRENALECTOMY AND ETHANOL ON CEREBRAL AMINO ACIDS IN THE RAT.
Hyperbaric oxygen toxicity prevention with succinate.
TLDR
Intracellular localization and thin layer chromatography studies with succinate-2, 3 14 C showed that succinate readily penetrated the blood brain barrier, but showed decreasing protection with increasing pressure.
GAMMA‐AMINOBUTYRIC ACID AND OXYGEN POISONING *
TLDR
The possibility must be considered that here too a deranged GABA metabolism is responsible for the observed disturbances in the functioning of the central nervous system and the degree of protection and GABA levels in the tissues is described in this paper.
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