HOP-1 Presenilin Deficiency Causes a Late-Onset Notch Signaling Phenotype That Affects Adult Germline Function in Caenorhabditis elegans.

@article{Agarwal2018HOP1PD,
  title={HOP-1 Presenilin Deficiency Causes a Late-Onset Notch Signaling Phenotype That Affects Adult Germline Function in Caenorhabditis elegans.},
  author={Ipsita Agarwal and Cassandra Farnow and Joshua Jiang and Kyung-Sik Kim and Donna E Leet and Ruth Z Solomon and Valerie A. Hale and Caroline Goutte},
  journal={Genetics},
  year={2018},
  volume={208 2},
  pages={
          745-762
        }
}
Functionally redundant genes present a puzzle as to their evolutionary preservation, and offer an interesting opportunity for molecular specialization. In Caenorhabditis elegans, either one of two presenilin genes (sel-12 or hop-1) facilitate Notch activation, providing the catalytic subunit for the γ secretase proteolytic enzyme complex. For all known… CONTINUE READING