HOIL-1L Interacting Protein (HOIP) Is Essential for CD40 Signaling

  title={HOIL-1L Interacting Protein (HOIP) Is Essential for CD40 Signaling},
  author={Bruce S. Hostager and Masaki Kashiwada and John D Colgan and Paul B. Rothman},
  booktitle={PloS one},
CD40 is a cell surface receptor important in the activation of antigen-presenting cells during immune responses. In macrophages and dendritic cells, engagement of CD40 by its ligand CD154 provides signals critical for anti-microbial and T cell-mediated immune responses, respectively. In B cells, CD40 signaling has a major role in regulating cell proliferation, antibody production, and memory B cell development. CD40 engagement results in the formation of a receptor-associated complex that… CONTINUE READING
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