HO-3867, a synthetic compound, inhibits the migration and invasion of ovarian carcinoma cells through downregulation of fatty acid synthase and focal adhesion kinase.

@article{Selvendiran2010HO3867AS,
  title={HO-3867, a synthetic compound, inhibits the migration and invasion of ovarian carcinoma cells through downregulation of fatty acid synthase and focal adhesion kinase.},
  author={Karuppaiyah Selvendiran and Shabnam Ahmed and Alex Dayton and Yazhini Ravi and Muthulakshmi L Kuppusamy and Anna Bratasz and Brian K. Rivera and T{\'a}m{\'a}s K{\'a}l{\'a}i and K{\'a}lm{\'a}n Hideg and Periannan Kuppusamy},
  journal={Molecular cancer research : MCR},
  year={2010},
  volume={8 9},
  pages={1188-97}
}
Fatty acid synthase (FAS) and focal adhesion kinase (FAK), which are overexpressed in a variety of human epithelial tumors, play a key role in the migration and invasion of cancer cells. Hence, strategies targeted at inhibiting the FAS/FAK proteins may have therapeutic potential for cancer treatment. The goal of the present study was to determine the effect of HO-3867, a synthetic compound, on the migratory ability of ovarian cancer cells and to understand the mechanistic pathways including the… CONTINUE READING

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