HNF4A genetic variants: role in diabetes.

  title={HNF4A genetic variants: role in diabetes.},
  author={Latisha D Love-Gregory and M. Alan Permutt},
  journal={Current opinion in clinical nutrition and metabolic care},
  volume={10 4},
PURPOSE OF REVIEW Variants in the hepatocyte nuclear factor 4alpha (HNF4A) gene play a role in the development of diabetes mellitus. Although genetic variation in and around HNF4A regulatory regions has received considerable attention, the significance of these variants in the common type 2 diabetes varies in the literature. This review will provide a general overview of recent genetic studies involving the evaluation of HNF4A as a contributor to the risk and pathophysiology of diabetes… CONTINUE READING


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