HNF1A gene polymorphisms and cardiovascular risk factors in individuals with late-onset autosomal dominant diabetes: a cross-sectional study

@article{Giuffrida2009HNF1AGP,
  title={HNF1A gene polymorphisms and cardiovascular risk factors in individuals with late-onset autosomal dominant diabetes: a cross-sectional study},
  author={Fernando M A Giuffrida and Gilberto Koiti Furuzawa and Teresa Sayoko Kasamatsu and Marcos Vin{\'i}cius Macedo de Oliveira and Andr{\'e} Fernandes Reis and S{\'e}rgio Atala Dib},
  journal={Cardiovascular Diabetology},
  year={2009},
  volume={8},
  pages={28 - 28}
}
BACKGROUND Type 2 diabetes mellitus (T2DM) is a genetically heterogeneous disease, hepatocyte nuclear factor-1 homeobox A (HNF1A) single-nucleotide polymorphisms (SNPs) playing a minor role in its pathogenesis. HNF1A is a frequent cause of monogenic diabetes, albeit with early-onset. Some uncommon subgroups like late-onset autosomal dominant diabetes mellitus (LOADDM) may present peculiar inheritance patterns with a stronger familial component. This study aims to investigate the relationship of… CONTINUE READING
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Al-Shali KZ, Hegele RA: Hypertriglyceridemia: its etiology, effects and treatment

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