HNE-induced 5-LO expression is regulated by NF-{kappa}B/ERK and Sp1/p38 MAPK pathways via EGF receptor in murine macrophages.

@article{Lee2010HNEinduced5E,
  title={HNE-induced 5-LO expression is regulated by NF-\{kappa\}B/ERK and Sp1/p38 MAPK pathways via EGF receptor in murine macrophages.},
  author={Seung Jin Lee and Chae Eun Kim and Kyo Won Seo and Chi Dae Kim},
  journal={Cardiovascular research},
  year={2010},
  volume={88 2},
  pages={352-9}
}
AIMS 5-Lipoxygenase (5-LO) has been suggested to be a modulator of atherosclerotic plaque instability and co-exists with 4-hydroxynonenal (HNE) in macrophages in atherosclerotic lesions. To determine the potential role for HNE in 5-LO expression, the molecular mechanisms of 5-LO expression were evaluated in HNE-stimulated macrophages. METHODS AND RESULTS A genomic sequence of the promoter 2.0 kb upstream of the transcription initiation site was amplified, and a series of sequentially deleted… CONTINUE READING