HNE--signaling pathways leading to its elimination.

  title={HNE--signaling pathways leading to its elimination.},
  author={Henry Jay Forman and Dale A. Dickinson and Karen E. Iles},
  journal={Molecular aspects of medicine},
  volume={24 4-5},
The oxidation of polyunsaturated fatty acids results in the production of HNE, which can react through both non-enzymatic and enzyme catalyzed reactions to modify a number of cellular components, including proteins and DNA. Multiple pathways for its enzyme catalyzed elimination include oxidation of the aldehyde to a carboxylic acid, reduction of the aldehyde to an alcohol, and conjugation of the carbon-carbon double bond to glutathione (GSH). Interestingly, the enzymes that result in HNE… CONTINUE READING