HMGN1 protein regulates poly(ADP-ribose) polymerase-1 (PARP-1) self-PARylation in mouse fibroblasts.

@article{Masaoka2012HMGN1PR,
  title={HMGN1 protein regulates poly(ADP-ribose) polymerase-1 (PARP-1) self-PARylation in mouse fibroblasts.},
  author={Aya Masaoka and Natalie R Gassman and Padmini Kedar and Rajendra Prasad and Esther W. Hou and Julie K. Horton and Michael Bustin and Samuel H. Wilson},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 33},
  pages={27648-58}
}
In mammalian cells, the nucleosome-binding protein HMGN1 (high mobility group N1) affects the structure and function of chromatin and plays a role in repair of damaged DNA. HMGN1 affects the interaction of DNA repair factors with chromatin and their access to damaged DNA; however, not all of the repair factors affected have been identified. Here, we report that HMGN1 affects the self-poly(ADP-ribosyl)ation (i.e., PARylation) of poly(ADP-ribose) polymerase-1 (PARP-1), a multifunctional and… CONTINUE READING

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