HMGI family proteins: architectural transcription factors in mammalian development and cancer.

@article{Zhou1998HMGIFP,
  title={HMGI family proteins: architectural transcription factors in mammalian development and cancer.},
  author={Xiaohui Zhou and Kiran K Chada},
  journal={The Keio journal of medicine},
  year={1998},
  volume={47 2},
  pages={73-7}
}
The HMGI proteins, a subfamily of the high mobility group (HMG) proteins, play an important role in the regulation of gene expression. They bind to AT-rich DNA sequences and alter DNA conformation to modulate the binding affinity of transcription factors to their cognate sites. They are expressed almost exclusively during embryogenesis and Hmgi-c null mice have the mouse pygmy phenotype. Studies have revealed the disruption of HMGI family genes in a variety of mesenchymal-derived benign tumors… CONTINUE READING

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