HMGCS2 promotes autophagic degradation of the amyloid-β precursor protein through ketone body-mediated mechanisms.

@article{Hu2017HMGCS2PA,
  title={HMGCS2 promotes autophagic degradation of the amyloid-β precursor protein through ketone body-mediated mechanisms.},
  author={Li-Tian Hu and Bing-lin Zhu and Yu-Jie Lai and Yan Long and Jing-Si Zha and Xiao-tong Hu and John H Zhang and Guo-Jun Chen},
  journal={Biochemical and biophysical research communications},
  year={2017},
  volume={486 2},
  pages={492-498}
}
HMGCS2 (mitochondrial 3-hydroxy-3-methylglutaryl-COA synthase 2) is a control enzyme in ketogenesis. The mitochondrial localization and interaction with APP (β-amyloid precursor protein) suggest that HMGCS2 may play a role in the pathophysiology of AD (Alzheimer's disease). Here we report that overexpression of HMGCS2 decreased levels of APP and related CTFs (carboxy-terminal fragments), which was largely prevented by an autophagic inhibitor chloroquine. In addition, HMGCS2 enhancement of… CONTINUE READING

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