HMGB1 regulates RANKL-induced osteoclastogenesis in a manner dependent on RAGE.

Abstract

High-mobility group box 1 (HMGB1), a nonhistone nuclear protein, is released by macrophages into the extracellular milieu consequent to cellular activation. Extracellular HMGB1 has properties of a pro-inflammatory cytokine through its interaction with receptor for advanced glycation endproducts (RAGE) and/or toll-like receptors (TLR2 and TLR4). Although… (More)
DOI: 10.1359/jbmr.080234

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