HMGB1 mediates depressive behavior induced by chronic stress through activating the kynurenine pathway.

@article{Wang2018HMGB1MD,
  title={HMGB1 mediates depressive behavior induced by chronic stress through activating the kynurenine pathway.},
  author={Bo Wang and Yong-Jie Lian and Wen-Jun Su and Wei Peng and Hongxia Zhao and Lin-Lin Liu and Hong Xia Gong and Ting Zhang and Chun-Lei Jiang and Y Wang},
  journal={Brain, behavior, and immunity},
  year={2018},
  volume={72},
  pages={
          51-60
        }
}
Our previous study has reported that the proactive secretion and role of central high mobility group box 1 (HMGB1) in lipopolysaccharide-induced depressive behavior. Here, the potential mechanism of HMGB1 mediating chronic-stress-induced depression through the kynurenine pathway (KP) was further explored both in vivo and in vitro. Depression model was established with the 4-week chronic unpredictable mild stress (CUMS). Sucrose preference and Barnes maze test were performed to reflect… CONTINUE READING