HMGB1 mediates IFN-γ-induced cell proliferation in MMC cells through regulation of cyclin D1/CDK4/p16 pathway.

@article{Feng2012HMGB1MI,
  title={HMGB1 mediates IFN-γ-induced cell proliferation in MMC cells through regulation of cyclin D1/CDK4/p16 pathway.},
  author={Xiaojuan Feng and Jun Hao and Qingjuan Liu and Lin Yang and Xin Lv and Yan Zhang and Lingling Xing and Ning Xu and Shuxia Liu},
  journal={Journal of cellular biochemistry},
  year={2012},
  volume={113 6},
  pages={2009-19}
}
Previous studies have revealed the elevated serum levels of High-mobility group box-1(HMGB1) and the interferon-γ (IFN-γ)-induced proliferation of renal mesangial cells in patients or experimental animals with systemic lupus erythematosus (SLE). However, it is still not elucidated whether HMGB1 involves in the pathogenesis of lupus nephritis (LN) and mediates IFN-γ-induced mesangial cell proliferation. Therefore, in the present study we demonstrated HMGB1 mRNA and protein levels were increased… CONTINUE READING