HMGB1 is a bone-active cytokine.

  title={HMGB1 is a bone-active cytokine.},
  author={Jieping Yang and Rita Shah and Alexander G. Robling and Evan Templeton and H. -S. Yang and Kevin J Tracey and Joseph P. Bidwell},
  journal={Journal of cellular physiology},
  volume={214 3},
High mobility group box 1 (HMGB1) is a chromatin protein that acts as an immunomodulatory cytokine upon active release from myeloid cells. HMGB1 is also an alarmin, an endogenous molecule released by dying cells that acts to initiate tissue repair. We have previously reported that osteoclasts and osteoblasts release HMGB1 and release by the latter is regulated by parathyroid hormone (PTH), an agent of bone remodeling. A recent study suggests that HMGB1 acts as a chemotactic agent to osteoclasts… CONTINUE READING


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