HMGB1 induces angiogenesis in rheumatoid arthritis via HIF-1α activation.

Abstract

High-mobility group box protein 1 (HMGB1), a nonhistone nuclear protein and a cytokine mediator, is implicated in the pathogenesis of rheumatoid arthritis (RA). Extracellular HMGB1 binds to its receptors and triggers downstream signal cascade leading to the perpetuation of synovitis and local tissue invasion. Here, we investigated a novel role of HMGB1 in… (More)
DOI: 10.1002/eji.201444908

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