HMGB1 as a DNA-binding cytokine.

  title={HMGB1 as a DNA-binding cytokine.},
  author={Ulf Andersson and Helena Erlandsson-Harris and H. -S. Yang and Kevin J Tracey},
  journal={Journal of leukocyte biology},
  volume={72 6},
HMGB1 (high mobility group box chromosomal protein 1), historically known as an abundant, nonhistone architectural chromosomal protein, is extremely conserved across species. As a nuclear protein, HMGB1 stabilizes nucleosomes and allows bending of DNA that facilitates gene transcription. Unexpectedly, recent studies identified extracellular HMGB1 as a potent macrophage-activating factor, signaling via the receptor for advanced glycation end-products to induce inflammatory responses. It is… CONTINUE READING