HMGB1-TLR4 signaling participates in renal ischemia reperfusion injury and could be attenuated by dexamethasone-mediated inhibition of the ERK/NF-κB pathway.

@article{Zhang2016HMGB1TLR4SP,
  title={HMGB1-TLR4 signaling participates in renal ischemia reperfusion injury and could be attenuated by dexamethasone-mediated inhibition of the ERK/NF-κB pathway.},
  author={Jiong Yi Zhang and Jumei Xia and Ying Zhang and Fang X Xiao and Jin Wang and H Gao and Yanyan Liu and Song Ji Rong and Ying Yao and Gang Xu and Junhua Li},
  journal={American journal of translational research},
  year={2016},
  volume={8 10},
  pages={4054-4067}
}
Studies have shown that the HMGB1-TLR4 (High-mobility group protein B1, toll-like receptor 4) pathway participates in renal ischemic reperfusion injury (IRI) and that dexamethasone (DEX) could protect the kidney against IRI. This study aims to examine the protective effects of DEX on renal IRI and further explore the possible mechanism of action. During… CONTINUE READING

Topics

Statistics

020040020172018
Citations per Year

167 Citations

Semantic Scholar estimates that this publication has 167 citations based on the available data.

See our FAQ for additional information.