HMGB1-DNA complex-induced autophagy limits AIM2 inflammasome activation through RAGE.

@article{Liu2014HMGB1DNACA,
  title={HMGB1-DNA complex-induced autophagy limits AIM2 inflammasome activation through RAGE.},
  author={Liying Liu and Minghua Yang and Rui Kang and Yunpeng Dai and Yan Yu and Fei Gao and Hongmei Wang and Xiaojun Sun and Xiuli Li and Jianhua Li and Haichao Wang and Lizhi Cao and Daolin Tang},
  journal={Biochemical and biophysical research communications},
  year={2014},
  volume={450 1},
  pages={
          851-6
        }
}
High mobility group box 1 (HMGB1) is a prototype damage-associated molecular pattern (DAMP) that can induce inflammatory and immune responses alone as well as in combination with other molecules such as DNA. However, the intricate molecular mechanisms underlying HMGB1-DNA complex-mediated innate immune response remains largely elusive. In this study, we demonstrated that HMGB1-DNA complex initially induced absent in melanoma 2 (AIM2)-dependent inflammasome activation, and promoted rapid release… CONTINUE READING
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