HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins

  title={HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins},
  author={Damien Bertheloot and Eicke Latz},
  booktitle={Cellular & Molecular Immunology},
Our immune system is based on the close collaboration of the innate and adaptive immune systems for the rapid detection of any threats to the host. Recognition of pathogen-derived molecules is entrusted to specific germline-encoded signaling receptors. The same receptors have now also emerged as efficient detectors of misplaced or altered self-molecules that signal tissue damage and cell death following, for example, disruption of the blood supply and subsequent hypoxia. Many types of… CONTINUE READING
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