HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

@article{Yanai2009HMGBPF,
  title={HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses},
  author={Hideyuki Yanai and Tatsuma Ban and Zhichao Wang and Myoung Kwon Choi and Takeshi Kawamura and Hideo Negishi and Makoto Nakasato and Yan Lu and Sho Hangai and Ryuji Koshiba and David Savitsky and Lorenza Ronfani and Shizuo Akira and Marco Emilio Bianchi and Kenya Honda and Tomohiko Tamura and Tatsuhiko Kodama and T. Taniguchi},
  journal={Nature},
  year={2009},
  volume={462},
  pages={99-103}
}
The activation of innate immune responses by nucleic acids is crucial to protective and pathological immunities and is mediated by the transmembrane Toll-like receptors (TLRs) and cytosolic receptors. However, it remains unknown whether a mechanism exists that integrates these nucleic-acid-sensing systems. Here we show that high-mobility group box (HMGB) proteins 1, 2 and 3 function as universal sentinels for nucleic acids. HMGBs bind to all immunogenic nucleic acids examined with a correlation… CONTINUE READING
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