• Corpus ID: 52229827

HMGB 1 influencing invasion , migration and proliferation abilities of breast cancer cells via PI 3 K / AKT signaling pathway

  title={HMGB 1 influencing invasion , migration and proliferation abilities of breast cancer cells via PI 3 K / AKT signaling pathway},
  author={Xiao-Cheng Yin and Hao Sun},
Objective: To investigate the effect of HMGB1 on invasion and migration of human breast cancer cells through the PI3K/AKT signaling pathway and the related mechanism. Methods: The MCF-7 cells were selected from those breast cancer cell lines with high expression of HMGB1 by Western blotting; HMGB1 knockdown lentivirus (LV3-HMGB1) was used to silence the expression of HMGB1; efficiency of LV3-HMGB1 silencing was measured by GFP fluorescence and Western blotting; effect of silencing HMGB1 on… 

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